Scientists generate functional, transplantable B cells from mice
Scientists generate functional, transplantable B cells from mice
Researchers have been able to function for long periods of functional B-1 cells released from mouse embryonic stem cells and are able to secrete natural antibodies after transplantation in the rats, researchers have reported in the Stem Cell Reports magazine on February 7.
Scientists are interested in B-1 cells produced from pluripotent stem cells because they can be clinically tested for a wide range of immune-related disorders.
"It is still challenging to produce transplantable immune cells with mouse embryonic stem cells, so achieving transplantable functional B-1 cells from the mouse embryonic stem cell is significant progress in the field," a senior study of the Center for Stem Cell Writer Momoko Yoshimoto says.
Regenerative Medicine at McGovern Medical School in Unhealthy in Houston "Take-home message is that a portion of the immune cells can be replaced by Cell Therapy using Pluripotent Stem Cells in the future."
Hemopoietic stem cells in adult bone marrow - Most of the bones are soft, spongy tissue in the center - providing various blood cells throughout life.
Hemopoietic stem cell transplantation is now done regularly to treat patients of cancer and blood and other disorders of the immune system.
But with the current in vitro methods, it is challenging to produce hematopoietic stem cells, which regulate the properties of cells in living organisms without gene manipulation.
In particular, bone marrow transplantation may fail to reorganize some immune cells called B-1 cells, which produce immunoglobulin M (IgM) antibodies - the first type of immune system makes it fight a new infection.
In addition to patients receiving stem cell transplantation, IgM deficiency also occurs in people with certain cancers, autoimmune diseases, allergic diseases, and gastrointestinal diseases, thereby increasing the risk of life infection.
In the new study, Yoshimoto and his colleagues demonstrated that functional, implantable B-1 cells can be produced from mouse embryonic stem cells without gene modifications.
Researchers have overcome the previous obstacles to prevent this blockage by using high-quality cell lines to support B cell development.
After transplanting the recipient into rats, stem cell-derived b progenitors matured in B-1 cells, which were maintained for more than 6 months and secretion of natural IgM antibodies.
Yoshimoto said, "To develop a cell therapy to provide natural fetal IgM and congenital B-1 cells, it is an important step to produce functional B-1 children in vitro from mouse embryonic stem cells."
In a future study, researchers will try to generate B cells from human-induced pluripotent stem cells, which can be used to treat patients with immunological disorders for cell therapy. Yoshimoto says, "It is the first step of a long process to translate our findings into humans."
Scientists generate functional, transplantable B cells from mice
Reviewed by Tech Gyan
on
February 12, 2019
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Reviewed by Tech Gyan
on
February 12, 2019
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